C5'-extended 2'-substituted phosphoramidite
Advantages of C5'-extended 2'-substituted phosphoramidites!
In the development of oligonucleotide drugs, precise structural control of the backbone will be the key to the next generation. Sapala Organics proposes the "C5'-extended 2'-substituted phosphoramidite" to overcome this challenge. Features of C5'-extended 2'-substituted phosphoramidite: The most significant feature of this product is that it physically extends the "distance" between nucleotides by elongating the C5' position. This allows for the resolution of steric hindrance that was difficult to avoid with conventional nucleic acid structures and enables optimal orientation control towards target molecules. Furthermore, a diverse range of modifications such as H, OMe, MOE, and F are available at the 2' position, supporting the advanced coexistence of nuclease resistance and binding affinity.
- Company：サパラ
- Price：Other
